When Any.DO -- the brains behind the popular iOS to-do app -- announced Cal for iOS last month, we had high hopes for its take on calendar functionality. Starting today, Cal will be available for download in the App Store, but we had a chance to play with it early to see what it was all about. The app marks the company's initial foray into a full-blown suite of productivity apps (as teased in their press release below), which will include, at some indeterminate point in the future, Any.DO's own e-mail app. Any.DO is determined to hit a home run with its life-management line, but does Cal live up to the hype? Read on to find out.
Can't be bothered to type something you want to search for? Snaplay is a reverse image search app that lets you snap a photo of a piece of media to retrieve associated music and videos which can then be viewed within the app. Its creators, London developer D&A, describe it as a 'Shazam for images'.
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Last summer, Mark Munoz was knocked out by Chris Weidman. Then he had to recover from a foot injury sustained while training for the Weidman bout. It was a rough turn of events for a fighter who had title shot hopes and who had been on a four-bout winning streak.
He turned to what so many turn to for comfort in tough times -- food. Munoz talked about his struggles on his website.
Battled through injury, self-doubt, and depression. I turned to food for comfort and what I found was more heartache. A never ending cycle of ?eating because I was sad and sad because I was eating.? I had to find peace and comfort in my faith in God, He shaped my life.
In the above picture, Munoz showed off how far he has come since January of this year. He went from 252 lbs. to 199 on June 27, which is not far from his fighting weight of 185 lbs. It's an impressive turnaround for a 35-year-old fighter.
This Saturday, he'll fight Tim Boetsch at UFC 162 with a whole new physique. It's his first chance to get back on the winning track after the loss to Weidman, who will fight for the middleweight belt on the same card. Will his newly healthy body make a difference? Make your pick here.
Too much of a good thing? Too many 'healing' cells delays wound healingPublic release date: 1-Jul-2013 [ | E-mail | Share ]
Contact: Cody Mooneyhan cmooneyhan@faseb.org 301-634-7104 Federation of American Societies for Experimental Biology
New research published in the Journal of Leukocyte Biology suggests that delayed wound healing in lymphedematous skin results from too many mast cells which leads to elevated IL-10 expression
Bethesda, MD -- Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing. An overabundance of these cells, however, also causes harm by leading to the overproduction of IL-10, which prevents certain white blood cells from reaching the wounded area. The work was conducted in mice with lymphedematous skin, and may one day provide better treatments for elderly individuals with skin ulcers in the lower extremities, for women with upper-extremity wounds following breast cancer surgery, and skin wounds of any type that are not healing as they should.
"Improvement of lymphedema is important for treatment of skin ulcers," said Makoto Sugaya, M.D., Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Tokyo in Tokyo, Japan. "It is not just fluid retention, but inflammatory cells and cytokines that cause delayed wound healing."
To make this discovery, scientists used two groups of mice. The first group showed severe lymphatic dysfunction. The second group was normal. Researchers administered skin wounds and found that the mice with lymphatic dysfunction showed delayed would healing as compared to the normal mice. Analysis showed that the delayed would healing in the lymphedematous skin is the result of too many mast cells and elevated IL-10 expression, both of which can now be therapeutic targets for future drug development.
"Wound healing is something most people take for granted until there's a problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, wound healing is a complex process involving immune as well as non-immune cells and problems that arise can be very serious, even if it started as a minor wound. This report provides an immunological explanation for why some wound healing is delayed, and it ultimately may help set a course for therapies that accelerate wound healing."
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The Journal of Leukocyte Biology (publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.
Details: Takayuki Kimura, Makoto Sugaya, Andrew Blauvelt, Hitoshi Okochi, and Shinichi Sato. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol July 2013 94:137-145; doi:10.1189/jlb.0812408; http://www.jleukbio.org/content/94/1/137.abstract
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Too much of a good thing? Too many 'healing' cells delays wound healingPublic release date: 1-Jul-2013 [ | E-mail | Share ]
Contact: Cody Mooneyhan cmooneyhan@faseb.org 301-634-7104 Federation of American Societies for Experimental Biology
New research published in the Journal of Leukocyte Biology suggests that delayed wound healing in lymphedematous skin results from too many mast cells which leads to elevated IL-10 expression
Bethesda, MD -- Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing. An overabundance of these cells, however, also causes harm by leading to the overproduction of IL-10, which prevents certain white blood cells from reaching the wounded area. The work was conducted in mice with lymphedematous skin, and may one day provide better treatments for elderly individuals with skin ulcers in the lower extremities, for women with upper-extremity wounds following breast cancer surgery, and skin wounds of any type that are not healing as they should.
"Improvement of lymphedema is important for treatment of skin ulcers," said Makoto Sugaya, M.D., Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Tokyo in Tokyo, Japan. "It is not just fluid retention, but inflammatory cells and cytokines that cause delayed wound healing."
To make this discovery, scientists used two groups of mice. The first group showed severe lymphatic dysfunction. The second group was normal. Researchers administered skin wounds and found that the mice with lymphatic dysfunction showed delayed would healing as compared to the normal mice. Analysis showed that the delayed would healing in the lymphedematous skin is the result of too many mast cells and elevated IL-10 expression, both of which can now be therapeutic targets for future drug development.
"Wound healing is something most people take for granted until there's a problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, wound healing is a complex process involving immune as well as non-immune cells and problems that arise can be very serious, even if it started as a minor wound. This report provides an immunological explanation for why some wound healing is delayed, and it ultimately may help set a course for therapies that accelerate wound healing."
###
The Journal of Leukocyte Biology (publishes peer-reviewed manuscripts on original investigations focusing on the cellular and molecular biology of leukocytes and on the origins, the developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes and other cells involved in host defense and inflammation. The Journal of Leukocyte Biology is published by the Society for Leukocyte Biology.
Details: Takayuki Kimura, Makoto Sugaya, Andrew Blauvelt, Hitoshi Okochi, and Shinichi Sato. Delayed wound healing due to increased interleukin-10 expression in mice with lymphatic dysfunction. J Leukoc Biol July 2013 94:137-145; doi:10.1189/jlb.0812408; http://www.jleukbio.org/content/94/1/137.abstract
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
BERLIN (Reuters) - Margot Woelk spent the last few years of World War Two eating lavish meals and fearing that every mouthful could mean death.
The former food taster for Adolf Hitler was served a plate of food and forced to eat it between 11 and 12 every morning for most of the last 2-1/2 years of the Nazi German leader's life.
If she did not fall ill, the food was packed into boxes and taken to Hitler at the Wolf's Lair, a military headquarters located deep in woodland, in what is today northeastern Poland.
"Hitler was a vegetarian so it was all vegetarian fare - it was very good food like white asparagus, wonderful fruits, peppers and cauliflower," the 96-year-old Berliner told Reuters.
Along with 14 other girls in their 20s, Woelk lived in fear that every meal she ate would be her last.
"We were always terrified that the food might be poisoned as England wanted to poison Hitler and he knew that from his spies so he employed young girls to taste his food," she said.
"We cried a lot and hugged each other. We asked each other: 'Will we still be alive tomorrow or not?'"
Woelk, who still has nightmares about her role as a food taster and did not speak about her experiences for decades after the war, said she and her family were against the Nazis and that she landed the job "through a series of coincidences".
Forced to leave her apartment in Berlin when allied bombing made it uninhabitable, Woelk gave up her secretarial job and moved in with her parents-in-law in the village of Gross-Partsch, then in eastern Germany and now part of Poland.
"The mayor there was a big Nazi and he had connections with the SS (a Nazi paramilitary organization) so I was forced into it right away. I had to work to earn money," she said.
She said she never saw Hitler, though she did see his dog.
Woelk said she heard the explosion on July 20, 1944 caused by a bomb that army generals had planted at the Wolf's Lair with the aim of taking Hitler's life.
At the time Woelk was watching a film with soldiers in a tent not far from the military headquarters.
"We heard this huge bang then we fell off the wooden benches we were sitting on. Someone shouted 'Hitler is dead' but we later found out that only his hand was injured."
After the failed assassination attempt, Woelk said she had to move into supervised accommodation and was held like a prisoner, denied access to a telephone and able to visit her parents-in-law only with SS officers as chaperones.
When Hitler killed himself in April 1945, Woelk fled to Berlin and went into hiding. Soviet forces were closing in on the German capital and Woelk was later pulled out of an air raid shelter and raped by Russian soldiers for a fortnight.
The other 14 food tasters who had stayed behind were all killed, she said.
After the war Woelk started a job in pension insurance and was surprised when her husband, in Russian captivity and presumed dead, turned up unexpectedly. She had not heard from him in two years and did not recognize him.
"I've had a life full of drama and now, at the age of 96, I'm back living in the same house I lived in before the war."
Can't be bothered to type something you want to search for? Snaplay is a reverse image search app that lets you snap a photo of a piece of media to retrieve associated music and videos which can then be viewed within the app. Its creators, London developer D&A, describe it as a 'Shazam for images'.
Last summer, Mark Munoz was knocked out by Chris Weidman. Then he had to recover from a foot injury sustained while training for the Weidman bout. It was a rough turn of events for a fighter who had title shot hopes and who had been on a four-bout winning streak.![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vnXuH4BcaJOmQ6D2ZTqycoP3XQpg5kqevFfkOkNf7AlmBgF9WQmJE5_2ruX2KQ_P6d-s_8br5-uHLDypptb7nrsMbXGssuAKdQxZImmWM=s0-d){kind=small}
Public release date: 1-Jul-2013
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