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Posted by: Posted by Pamela Hogle - Dec 17, 2012 - 12:10 AM PSTContent Type: Article
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Long heralded as the darling of the open web, the standards for HTML5 haven't actually been finalized by the W3C -- it was just recently that the international consortium pledged to get it done by 2014. So it's good to hear the group just hit a significant milestone on the road to that goal by publishing the full definition for the spec this Tuesday. With that accomplished, the next step is interoperability and performance testing to make sure HTML5 plays nice with any and all browsers, servers and other web tools. The W3C hopes that this will bring "broad HTML 5 interoperability" by 2014, which fits right in to the organization's philosophy of bringing the entirety of the web -- however divisive -- together.
Filed under: Internet
Via: The Inquirer
Source: W3C
Source: http://www.engadget.com/2012/12/18/w3c-completes-html5-definition/
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WASHINGTON (AP) ? Democrats say meaningful action in the wake of the school shootings in Connecticut must include a ban on military-style assault weapons and a look at how the nation deals with individuals suffering from serious mental illness.
Several Democratic lawmakers and Independent Sen. Joe Lieberman said it was time to take a deeper look into the recent spate of mass shootings and what can be done to prevent them. Gun control was a hot topic in the early 1990s, when Congress enacted a 10-year ban on assault weapons. But since that ban expired in 2004, few Americans have wanted stricter laws and politicians say they don't want to become targets of a powerful gun-rights lobby.
Gun-rights advocates said that might all change after the latest shooting that killed 20 children aged 6 or 7. Police say the gunman, Adam Lanza, was carrying an arsenal of ammunition and used a high-powered rifle similar to the military's M-16.
On Monday, Sen. Joe Manchin, a lifelong member of the National Rifle Association, said it was time to discuss gun policy and move toward action on gun regulation. The conservative West Virginia Democrat said Monday he agrees with New York City Mayor Michael Bloomberg, who has advocated banning the sale of assault weapons.
Manchin is the most prominent gun rights advocate to speak after the shooting, telling MSNBC that he is a "proud outdoorsman and hunter, but this doesn't make sense."
At a Sunday night service in Newtown, Conn., the site of Friday's massacre, President Barack Obama did not specifically address gun control. But he vowed, "In the coming weeks I'll use whatever power this office holds to engage my fellow citizens, from law enforcement to mental health professionals to parents and educators in an effort aimed at preventing more tragedies like this."
He added: "Are we really prepared to say that we're powerless in the face of such carnage, that the politics are too hard? Are we prepared to say that such violence visited on our children year after year after year is somehow the price of our freedom?"
Sen. Chuck Schumer, D-N.Y., said the nation "could be at a tipping point ... a tipping point where we might actually get something done" on gun control. He and other Democrats, as well as Lieberman, said they want to ban the sale of new assault weapons and make it harder for mentally ill individuals to obtain weapons. Lieberman said a new commission should be created to look at gun laws and the mental health system, as well as violence in movies and video games.
"Assault weapons were developed for the U.S. military, not commercial gun manufacturers," Lieberman said before the Newtown vigil Sunday night.
"This is a moment to start a very serious national conversation about violence in our society, particularly about these acts of mass violence," said the Connecticut senator, who is retiring at the end of the year.
Sen. Dianne Feinstein, D-Calif., said she will introduce legislation next year to ban new assault weapons, as well as big clips, drums and strips of more than 10 bullets.
"It can be done," Feinstein told NBC's "Meet the Press" of reinstating the ban despite deep opposition by the powerful National Rifle Association and similar groups.
Bloomberg said Obama could use executive powers to enforce existing gun laws, as well as throw his weight behind legislation like Feinstein's.
"It's time for the president, I think, to stand up and lead and tell this country what we should do ? not go to Congress and say, 'What do you guys want to do?'" Bloomberg said."
Gun-rights activists had remained largely quiet on the issue since Friday's shooting, all but one declining to appear on the Sunday talk shows.
David Gregory, the host of "Meet the Press," said NBC invited all 31 "pro-gun" senators to appear on Sunday's show, and all 31 declined. All eight Republicans on the Senate Judiciary Committee were unavailable or unwilling to appear on CBS' "Face the Nation," host Bob Schieffer said.
Rep. Louie Gohmert, R-Texas, was the sole representative of gun rights' activists on the various Sunday talk shows. In an interview on "Fox News Sunday," Gohmert defended the sale of assault weapons and said that the principal at Sandy Hook Elementary School, who authorities say died trying to overtake the shooter, should herself have been armed.
"I wish to God she had had an M-4 in her office, locked up so when she heard gunfire, she pulls it out and she didn't have to lunge heroically with nothing in her hands. But she takes him (the shooter) out, takes his head off before he can kill those precious kids," Gohmert said.
Gohmert also argued that violence is lower in cities with lax gun laws, and higher in cities with stricter laws.
"The facts are that every time guns have been allowed ? conceal-carry (gun laws) have been allowed ? the crime rate has gone down," Gohmert said.
Gun-control advocates say that isn't true. A study by the California-based Law Center to Prevent Gun Violence determined that 7 of the 10 states with the strongest gun laws ? including Connecticut, Massachusetts and California ? are also among the 10 states with the lowest gun death rates.
"If you look at the states with the strongest gun laws in the country, they have some of the lowest gun death rates, and some of the states with the weakest gun laws have some of the highest gun death rates," said Brian Malte of the Brady Campaign to Prevent Gun Violence.
___
Associated Press writers Jim Kuhnhenn and Josh Lederman contributed to this report.
Source: http://news.yahoo.com/gun-control-debate-begins-simmer-massacre-080649736--politics.html
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Instagram is updating its privacy policy in order to share data with Facebook, which bought Instagram earlier this year.?
Kevin Systrom, chief executive of Instagram, the popular photo-sharing app now owned by Facebook, displays his photo on a mobile phone during an interview with Reuters at the LeWeb technology conference in Aubervilliers, near Paris, on Dec.4, 2012.
Reuters
EnlargeBeginning Jan. 16, Instagram will institute a new privacy policy allowing it to share data with Facebook, which acquired Instagram earlier this year. In a blog post, Instagram promised that?"nothing has changed about your photos? ownership or who can see them."
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The new policy, Instagram?continued, was a matter of necessity.
"Our updated privacy policy helps Instagram function more easily as part of Facebook by being able to share info between the two groups," Instagram wrote. "This means we can do things like fight spam more effectively, detect system and reliability problems more quickly, and build better features for everyone by understanding how Instagram is used."?
You can access the full revised privacy policy here.?
But if you're looking for the most pertinent part of the policy, navigate down to section 3, which is titled "Sharing of Your Information." An excerpt:?
We may share User Content and your information (including but not limited to, information from cookies, log files, device identifiers, location data, and usage data) with businesses that are legally part of the same group of companies that Instagram is part of, or that become part of that group ("Affiliates"). Affiliates may use this information to help provide, understand, and improve the Service (including by providing analytics) and Affiliates' own services (including by providing you with better and more relevant experiences). But these Affiliates will honor the choices you make about who can see your photos.
Over at CNET, Don?Reisinger zeroes in on that upper-cased (and extremely vague) mention of "Affiliates."?
"Instagram doesn't specifically identify which companies are considered affiliates," Reisinger writes,?"but the company does note that they're providing their 'own services (including providing you with better and more relevant experiences).' In other words, advertising could be included."
It's been a busy week for Instagram, a photo-sharing platform launched two years ago by?Kevin Systrom?and Mike?Krieger. Last week,?Instagram?dropped support?for "Twitter?cards," a design feature that allowed users to embed multimedia content into their tweets. Twitter promptly launched a photo filter platform of its own, opening the door for all sorts of punditry and?procrastinating about the brewing war between Twitter and Facebook.?
For?more tech news, follow us on?Twitter @venturenaut.
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BAGHDAD (AP) ? A wave of bombings across Iraq on Monday targeted residents of ethnically disputed areas and Shiite pilgrims, killing 19 people and wounding dozens.
The attacks deepen fears that militants are seeking to reignite ethnic and sectarian violence in the country, where tensions remain high over areas contested between Iraq's central government and the Kurdish minority.
The deadliest of Monday's attacks took place in al-Mouafaqiyah, a village inhabited by families from the Shabak ethnic group. Seven people were killed and 11 were wounded in the bombing, according to police officials.
The village lies near the city of Mosul, 360 kilometers (225 miles) northwest of Baghdad, and is claimed by Arabs, Turkomen and Kurds. The Shabak have their own distinct language and religious beliefs.
Elsewhere in the north, two car bombs went off in a majority Turkomen neighborhood in the city of Tuz Khormato, killing five people and wounding 26, said Mohammed al-Asi, a spokesman for Salahuddin provincial council.
Like the area near the other attack, Tuz Khormato, about 210 kilometers (130 miles) north of Baghdad, has a mix of Arabs, Kurds and Turkomen competing for control of the city.
Tuz Khormato borders the autonomous Kurdish region. Last month, it was the scene of a deadly shootout between Kurdish guards and Iraqi police that killed one civilian. The Iraqi military and Kurdish fighters responded by moving additional troops into disputed areas, raising the possibility of further clashes.
Elsewhere Monday, police said a roadside bomb hit a bus carrying Lebanese Shiite pilgrims near Samarra, killing one Lebanese national plus the Iraqi driver and wounding eight others, including five Lebanese. Also, a car bomb went off on a bus carrying Iranian pilgrims heading to Samarra, killing two, including an Iranian national.
Another car bomb went off in a commercial area in downtown Baghdad in the afternoon, killing three people and wounding ten, police and health officials said.
Medics in a nearby hospital confirmed the casualties. All officials spoke on condition of anonymity because they were not authorized to speak to the media.
On Sunday, a series of attacks targeting two other cities in disputed northern areas left at least eight dead and dozens wounded.
It was unclear who is behind the latest violence, though Sunni Arab insurgents frequently use coordinated bomb attacks to try to undermine the Shiite-led government's authority.
Source: http://news.yahoo.com/wave-bombings-kills-19-across-iraq-130747156.html
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The Vegas Pro 9 collection integrates two powerful applications that work seamlessly together to provide an efficient and intuitive environment for video and broadcast professionals. This comprehensive suite offers the most robust and progressive platform available for content creation and production. With broad format support, superior effects processing, unparalleled audio support, and a full complement of editorial tools, the Vegas Pro 9 collection streamlines your workflow. From acquisition to delivery, from camera to Blu-ray Disc?, the Vegas Pro 9 collection delivers exactly what you need to produce outstanding results.
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Source: http://www.afterdawn.com/software/audio_video/video_editing/vegas_pro_64.cfm
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BAGHDAD (Reuters) - Bombs exploded in three towns and villages in Iraq's disputed territories on Monday, killing at least 11 people in the second day of attacks in areas at the center of a feud between Baghdad and autonomous Kurdistan.
Two blasts hit a Shi'ite district in Tuz Khurmato, killing at least four and wounding 24 and a truck bomb killed seven in a Shabak minority area near Mosul, 390 km (240 miles) north of the capital, security and local officials said.
Another car bomb hit a second village near Mosul without causing any casualties, police said.
No one claimed responsibility for Monday's blasts. But the areas have been a potential flashpoint between the Arab-led central government and ethnic Kurds since the last American troops left the country a year ago.
The ethnically mixed, disputed territories are a swath of land marking Iraq from the area administered by Kurds in the north, including the sensitive city of Kirkuk, which sits atop some of the world's largest oil reserves.
Last month, both Baghdad and Kurdistan sent troops from their respective armies to reinforce posts around towns in the disputed territories, escalating tensions in their long-running fight for control of land and oil wealth.
(Writing by Patrick Markey)
Source: http://news.yahoo.com/bombs-blasts-kill-11-iraqs-disputed-areas-070542394.html
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TOKYO (Reuters) - Japan's conservative Liberal Democratic Party (LDP) won a landslide victory in Sunday's election for parliament's lower house, TV exit polls showed, returning it to power after a three-year-hiatus with ex-Prime Minister Shinzo Abe at the helm.
An LDP win will usher in a government committed to a tough stance in a territorial row with China, a pro-nuclear power energy policy despite last year's Fukushima disaster, and a radical recipe of hyper-easy monetary policy and big fiscal spending to end persistant deflation and tame a strong yen.
The LDP was to win 296 seats in the 480-member lower house, while its ally, the New Komeito was to win 32 seats, TV Asahi's exit poll showed. That would give them the two-thirds majority needed to over-ride the upper house and break a policy deadlock that has plagued successive governments for half a decade.
The victory will give the 58-year-old Abe, who quit the top job in 2007 citing ill health after a troubled year in office, a second shot at running the world's third-biggest economy.
The ruling Democratic Party of Japan would get only 65 seats, the TV Asahi exit poll showed. The new right-leaning Japan Restoration Party would get 46 seats. Exit polls by other broadcasters were broadly in line those forecasts.
(Reporting by Linda Sieg; Editing by Edmund Klamann)
Source: http://news.yahoo.com/japan-opposition-ldp-wins-landslide-exit-polls-111944098.html
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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/aS2-M3z23Dg/viewtopic.php
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ANALYSIS
By Greg Bedard
NBCSports.com contributor
updated 6:37 p.m. ET Dec. 15, 2012
|
It?s a bicoastal and interconference grudge match that pits the best scoring offense from New England (36.3 per game) against the toughest scoring defense from San Francisco (14.2) in what could be a Super Bowl preview.
The Patriots (10-3), who have won seven straight games overall and 20 in December, have been dominating. Four of their last six victories have been by at least 28 points, including Monday night?s 42-14 victory over the Texans, who had one loss and are the AFC?s top seed.
The 1999 Rams (five) and the '96 Packers (six) ? both of whom won the Super Bowl those seasons ? are the only other teams since the 1970 merger to win more than four games by 28 points in a season.
?Well, it?s a big challenge and a big task to put pressure on Tom Brady when he?s so good with every detail of his game,? 49ers coach Jim Harbaugh said. ?Everything is so refined. There are not a lot of tips you can get or clues even when he?s in the shotgun for example. It?s a big task and that?s something that we would like to get done. And I think we?re up for it and like I said, our guys are excited to go play this game.?
The defense for the 49ers (9-3-1) is second overall in yards allowed and equally as good against the run (tied for second) and the pass (second).Outside linebacker Aldon Smith has 19.5 sacks and needs just three to tie Michael Strahan?s single-season record.
?A really, really talented defense,? said Patriots offensive coordinator Josh McDaniels. ?I mean, this is as good as we?re going to face. We certainly have a great deal of respect for the way they?re coached, the way they way, the style of defense they have. They have great players at all three levels of their defense, Pro-Bowl caliber players.
"This will be a tremendous challenge for us. Really, we?re going to have our hands full with just the preparation and getting ourselves ready to play against a really, really special defense.?
A special offense, led by perhaps the league?s most valuable player in Brady. A special defense that boasts players like Smith, Justin Smith, Patrick Willis and NaVorro Bowman.Should be a special night.
A look at the three keys for each team:
49ERS
Hold the fort early: During their seven-game winning streak, the Patriots have outscored their opponents by nearly 100 points (163-64) in the first half. They come out with an aggressive gameplan and a quick no-huddle attack with the goal of jumping on the opponent early and taking them out of their offensive gameplan.
That plays right into the hands of the Patriots? defense, which has improved of late but still has some issues in the pass game. The 49ers are a team that likes to stay balanced offensively and let their defense do much of the heavy lifting, which allows second-year quarterback Colin Kaepernick to stay in his comfort zone.
The 49ers have not had a chase many high-powered offenses from behind this season. If they fall behind Tom Brady early, the 49ers might not have the ability to come from behind with an inexperienced quarterback.
Be physical with Welker and Hernandez: With tight end Rob Gronkowski possibly out after forearm surgery, receiver Wes Welker and Aaron Hernandez are carrying the load for the Patriots? offense because they are so difficult to cover one-on-one.
Welker has to be bracketed by a defensive back and linebacker because no cornerback can deal with the option routes that he and Brady work so well.
Hernandez is a matchup nightmare. He?s too big for most defensive backs, and he?s too quick for most linebackers. The 49ers have two good cover linebackers in Willis and Bowman. Help would be nice from a safety, but at least the outside linebackers have to get a hand on Hernandez as he?s coming off the line. The Texans allowed too many free releases and Hernandez is almost impossible to stop if he gets a free release.Watch the play-action: Nobody runs more or better play-action than the Patriots. Conversely, the 49ers? inside linebackers and safeties like to play downhill to stuff the run. The Patriots are going to stay balanced and run their play-action passes, which killed the Texans. If the 49ers bite on the fakes, they?re going to be torched as bad as Houston and the score is going to get out of hand.
PATRIOTS
Stop the run: The 49ers will give standout running back Frank Gore all the touches he can handle to make sure quarterback Colin Kaepernick doesn?t have to beat the Patriots by himself. If the Patriots can limit the run, that puts Kaepernick in tough down-and-distance situations on second and third downs, which will make it easier to defend.
Make Kaepernick beat you from the pocket: Expect the Patriots to be very careful with the pressure they apply to Kaepernick because he?s a dynamic athlete that can take off from the pocket and score 50-yard touchdowns, which he did last week against the Dolphins. He?s also at his best throwing the ball as plays break down.
It?s vitally important for the Patriots make Kaepernick beat them by being a pocket passer. It?s not his strength. He?s still growing in the position, so his reads and delivery are slow. His reads are also basic, so the Patriots should be able to get him off his first option, which make him even more indecisive and prone to turnovers, which the Patriots get a league-leading rate (plus 24).Protect Brady: The Patriots are going to have a lot to handle on the offensive line between outside linebackers Aldon Smith and Ahmad Brooks, and ends Justin Smith and Ray McDonald. The Smith duo is perhaps the best stunting tandem in the league. They will work together by having Justin Smith take offensive linemen outside, while Aldon Smith crosses behind and rushes from the inside.
The Patriots have had a lot of trouble (Giants in both Super Bowls) dealing with stunting lines. The Patriots can help that and Brady by running the ball reasonably well. If they do that, the Patriots should be able to use their playaction game down the field for big plays, and also to work some screen passes to slow down the rush. Brady is extremely tough to beat if the defense is having to worry about the run and the pass. The rush doesn?t come quick enough to bother him.? 2012 NBC Sports.com? Reprintsadvertisement
More newsReutersPFT's picks: In a monstrous Week 15, also look for the Packers to win in Chicago, the Broncos to win in Baltimore and the Giants to win in Atlanta.
Source: http://nbcsports.msnbc.com/id/50182871/ns/sports-nfl/
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Emmanuel Dunand / AFP - Getty Images
The second deadliest school shooting in U.S. history sent crying children spilling into the school parking lot as frightened parents waited for word on their loved ones.
By John W. Schoen, NBC News
NEWTOWN, Conn. -- The outpouring of shock and grief from around the world over the horrific events in this picturesque New England town has given way to another widely felt, powerful emotion: the urge to support the shattered families of the victims. ??
?I just had a lady call from Montana,? said Scudder Smith, publisher of the Newtown Bee, the local paper. "She said she?s going to send me a box of bears to distribute when the time is right so the kids can hug some bears.?
As details of Friday?s mass shooting at Sandy Hook Elementary continue to unfold, residents remain stunned by the mayhem unleashed by a lone gunman. On Saturday, authorities disclosed the names of the 12 girls, eight boys and six adult women who were killed?in the nation's second-worst school shooting.?
The scope of the tragedy has been matched by a torrent of offers to help.
Since just hours after the massacre, local churches and social service agencies have been besieged with phone calls and emails from around the country and the world -- as far away as Taiwan, Australia and West Africa. Some callers express a sense of powerlessness in trying to help shattered families rebuild their lives, along with a bewilderment in trying to know what to do.
Leo McIlrath, chaplain at the Lutheran Home of Southbury, said one way to support the wounded community is to ?pray from a distance.?
?That?s more powerful than anything they can do up close - including providing food or shelter," he said. "We do all that already in this community. We don?t need people to put something in a box, I don?t think, and send it here. We need to be as of one mind and one heart and one spirit. And I feel that?s coming across.?
The outpouring of global grief has generated a flood of offers of financial contributions, according to Newtown Savings Bank President John Trentacosta.
?We?ve been hearing from people all over the country asking how they can help and what they can do to support he families,? he said. ?This all happened so quickly.?
The small Connecticut town of Newtown is grieving in the aftermath of Friday's deadly school shootings. NBC's Anne Thompson reports.
In response, several groups have set up websites to accept contributions, including a joint effort between Newtown Savings and the United Way of Western Connecticut. The Sandy Hook School Support Fund?is accepting donations via the Web, or by check mailed to Sandy Hook School Support Fund, Newtown Savings Bank, 39 Main St., Newtown CT 06470. Donations are also being accepted at the bank's local branches.
Local residents have also taken up the cause. Neighbors and friends have been preparing meals for the?bereaved?families, and counseling agencies have tapped an influx of volunteers to help cope with the psychological trauma. ??
Santas for Sandy Hook
Clad in Santa caps and armed with a handwritten "Santas for Sandy Hook" sign, Zoe Walter, 21, her sister and a friend stood outside a local coffee and donuts shop Saturday asking for donations to the newly created support fund.
As she briefly silenced her handbell, Walter said she was shaken by the killings.
"I just want them to know that we care and we're here, and we'll do anything that we can (to) help," said Walter, a college student, as she broke down in tears. "I just want them to know that we're thinking about them."
Countries that have experienced similar tragedies tonight stand shoulder-to-shoulder with America as it mourns the deaths of 28, most of them young children. NBC's Annabel Roberts reports.
At New Hope Community Church, pastor Jim Solomon has been fielding calls since shortly after the Friday morning tragedy.
?We?ve been getting what seems like literally thousands of inquiries,? he said. ?I?m touched by the level of support not only from all around our nation but from around the world. They want to do something practical.?
In response, Solomon has also set up a fund on the church?s Web site, asking contributors for suggestions on how the money should be spent.
Antonio Lacerda / EPA
A woman puts some flowers next to crosses on Copacabana beach, Rio de Janeiro. Brazil, on Saturday as a tribute to the shooting victims at Sandy Hook Elementary School in Newtown, Conn.
?If they indicate what the funds are for, the church treasurer is going to dispense those funds to help each of the particular families,? he said. ?We?re going to use that money to help each family with food or funeral and memorial services, burial expenses or any other needs so we can help them in a very practical way."
Solomon, a counselor, is also a board member at Newtown Youth and Family Services, which is offering free counseling to victims? families and other residents.
In the aftermath of natural disasters, communities often see an influx of donated food, clothing and other emergency supplies. Local clergy say the school shooting in Newtown was a very different type of disaster, calling for a very different response.
?There?s an awful lot to just knowing that people care,? said Rev. Raymond Petrucci, a chaplain at nearby Danbury Hospital. ?If there?s any way people can communicate through the public media or whatever forms of saying, ?We truly are supporting and praying for you hoping for you,? that type of emotional support - especially for that community, it?s already close-knit - is the most appropriate way of approaching this.?
Mandel Ngan / AFP - Getty Images
Gun control supporters take part in a candlelight vigil at Lafayette Square across from the White House on Saturday.
In a world awash in social media, grief also flowed online.
On Twitter, the #Newtown hashtag emerged almost immediately, promptly flooded with emotional outpouring and soon began trending. On Google+, many gathered around the topic "Sandy Hook" for consolation. Facebook users created multiple pages to share news and prayers with friends.
Reddit users inundated the Connecticut subreddit with fundraising initiatives, local news, and opportunities to "vent your fears, anger, frustration and anything else." By midday Saturday, the local NewtownPatch had drawn more than 500 ?I want to help? comments on a page devoted to supporting local residents.
In Newtown, some people are showing their support just by showing up.
At a Friday night vigil at St. Rose of Lima church, the crowd spilled out into the freezing weather, trying to make sense of the tragedy. Another townwide vigil is planned for Sunday night at Newtown High School.
Arshad / Zuma Press
Pakistani children light candles to pay tribute to U.S. elementary school shooting victims in the southern Pakistani port city of Karachi.
?I know people will be coming from out of town,? said McIlrath. ?There using the high school because there is no church big enough.?
McIlrath, who plans to speak at the service, was still working out what he wants to say. ???
?I heard a lot of people say the joy is gone,? said McIlrath. ?I want to say, ?No, the joy isn?t stolen from us - no more than Grinch stole Christmas. Death isn?t going to steal the joy out of this community.?
NBC's Miranda Leitsinger and?Rosa Golijan contributed to this report.
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The holidays may be just around the corner, but the pace of news shows no sign of slowing. So here's another quick recap of the week's main Android events around the world. It's been a busy week packed with device launches on various UK networks, app updates from Google and the BBC, as well as review and first impressions features here on AC.
Check past the break for this week's round-up.
 |  |
Source: http://feedproxy.google.com/~r/androidcentral/~3/fTuE6DiH5Tg/story01.htm
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I'm a self-taught web designer. In other words, a LOT of hard work (and in some cases, tears) went into the creation of this site. So unless otherwise stated, please respect my copyrights and intellectual property - including but not limited to projects, images, and posts. You may NOT use original content and designs from this site (The Ugly Duckling House - uglyducklinghouse.com) for commercial use without license, and please do not pass content from this site off as your own.
Source: http://www.uglyducklinghouse.com/2012/12/fixing-holiday-home-chaos-with-hgtvs.html
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AUSTIN, Texas -- Texas put up $3 billion in taxpayer money and promised cancer breakthroughs. But a criminal investigation, widespread rebuke from scientists and the resignations of embattled state officials came faster than medical discoveries.
The Cancer Prevention and Research Institute of Texas launched in 2009, flaunting the second-biggest trough of cancer research dollars in the country. Nobel laureates eagerly took jobs with the agency and celebrity Lance Armstrong lent visible and then-coveted support. It was an unprecedented state-run battle against a worldwide killer.
Three years later, it's become unhinged by suggestions of politics and personal profit and is on the ropes.
"People expected that we get some good results. Not that we make people rich in private companies doing cancer research," said Cathy Bonner, a cancer survivor who was a close aide to former Texas Gov. Ann Richards, and who helped brainstorm the idea for CPRIT. "I can't imagine anything lower than misuse of research money that's meant to save people's lives."
Embroiled by two lucrative grants approved despite scant review ? or none at all, in one case ? CPRIT is ending a year of turmoil saying the beleaguered agency is cooperating with separate prosecutor investigations. One is by a public corruption unit that convicted former U.S. House Majority Leader Tom DeLay on money laundering charges, and is beginning this probe trying to recover key internal emails CPRIT says it cannot retrieve.
The investigations opened last week after CPRIT revealed its latest and most serious blunder: Giving a private biomedical startup, Dallas-based Peloton Therapeutics, an $11 million award in 2010 without ever scrutinizing the merits of the company's proposal. The discovery came on the heels of the agency funding a $20 million project roundly condemned for not first undergoing an independent scientific review.
On Friday, the federal National Cancer Institute ? which confers CPRIT the prominent status of being an approved funding entity ? confirmed it was evaluating "recent events" at the state agency.
Amid the escalating troubles, an agency that doled out more than $800 million in three years has practically ground to a halt.
CPRIT's peer-review boards that evaluate research proposals are empty ? virtually all members quit in protest, including the chief science officer and the head of the science review council, both Nobel prize winners. They didn't leave quietly: Dr. Phillip Sharp, professor at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, said agency leaders "dishonored" the integrity of the independent review process and suggested "suspicions of favoritism" were at hand.
On the other end of treating cancer ? putting drug discoveries on the market and in the hands of patients ? Chief Commercialization Officer Jerry Cobbs resigned in November after the irregularities behind Peloton's funding were uncovered. The agency has said Peloton was unaware its proposal bypassed review, and the company has declined comment.
Executive Director Bill Gimson then completed an extraordinary purging of the agency's leadership last week, saying he would step down from the $300,000-a-year job he held since CPRIT formed. His Dec. 10 resignation letter is dated the same day the Texas attorney general's office informed Gimson it was launching a wide inquiry into the agency's operations.
Months of upheaval has become even too much for one public relations superpower. Hill & Knowlton Strategies severed its consulting deal with CPRIT last week, telling the agency in a letter that "the ongoing issues and challenges that have confronted the organization over recent months have greatly exceeded the scope of work outlined in the original contract."
Cancer-fighting groups worry Texas lawmakers will be next to abandon CPRIT.
"The internal dynamics are concerning, and we need to know exactly what's going on," said James Gray, a government relations director for the American Cancer Society. "But the mission and work of CPRIT is vital in saving lives today, and also in the future."
CPRIT was created with a built-in expiration date. Texas voters approved a constitutional amendment in 2007 to launch a $3 billion cancer-fighting effort, but gave the state only a decade to do it. Apart from funding research in university laboratories and infusing private biotech startups with cash ? including Peloton ? the agency also provides money for hundreds of thousands of preventive screenings, such as for breast cancer, across Texas.
Gov. Rick Perry and other elected leaders are now talking tough about transparency and getting to the bottom of the Peloton grant. The state's key budget-writing committee added a review of the agency to a hearing agenda for Thursday, though there appears to be little appetite among lawmakers to cut off CPRIT.
Prosecutors launched their investigations last week without alleging any criminal misconduct. But their broad scope will include trying to recover internal agency emails surrounding the Peloton grant that Gimson has said are no longer available.
"We've been down that road many times," said Gregg Cox, director of the Travis County district attorney's public integrity unit.
CPRIT is among fewer than two dozen funding entities in the nation approved by the National Cancer Institute. Aleea Farrakh Khan, an NCI spokeswoman, said the institute has not directly contacted CPRIT during its evaluation and no decisions have been made.
___
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Source: http://www.huffingtonpost.com/2012/12/15/texas-cancer-agency-_n_2307946.html
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Dec. 14, 2012 ? A multicenter study led by researchers at UC Davis describes new, paradoxical characteristics of the most common type of breast cancer. The findings shed light on how the disease can evade treatment and could improve diagnosis and treatment of breast cancer.
The research, led by Jian Jian Li, director of translational research in the UC Davis Department of Radiation Oncology, examined breast tumors previously thought to lack the HER2 protein, which, when over-expressed, is associated with disease recurrence. Instead, researchers found in the tumors small groups of aggressive, treatment-resistant HER2-positive breast cancer stem cells (BCSCs). The findings will be published Dec. 15 in Clinical Cancer Research.
"These BSCSs are very resistant to traditional treatments, which can lead patients to relapse," said Li, the study lead author. "Despite chemotherapy, radiotherapy or even surgery, the cancer is still recurrent. These findings change our concept of breast cancer because now we know HER2-negative breast cancers can be treated effectively with anti-HER2 treatments."
In the past decade scientists and clinicians have developed a better understanding of how breast cancers differ on the cellular level. Whether a tumor contains HER2, an estrogen receptor protein, a progesterone receptor protein or all three or none can have an enormous impact on the tumor's aggressiveness, the patient's overall prognosis and treatment choices.
HER2-positive breast cancers are routinely treated with drugs that target the HER2 protein, such as Herceptin or Tykerb, with good results. However, until recently, there has been little reason to administer these targeted treatments to patients with HER2-negative cancer.
The team, which included researchers from the University of Michigan Comprehensive Cancer Center, the Holden Comprehensive Cancer Center at the University of Iowa, Emory University School of Medicine and MD Anderson Cancer Center, isolated the HER2-positive BCSCs from irradiated, HER2-negative breast tumors. They also analyzed the stem cells for CD44 and CD24, cell surface proteins that indicate cancer aggressiveness and act as BCSC markers.
The team found that the HER2-positive, CD44 positive, CD24 negative/low BCSCs were more aggressive and highly resistant to radiotherapy. These characteristics were significantly reduced by Herceptin or short interfering RNA. HER2 and CD44 positive BCSCs were found in 57.1 percent of primary tumors and 84.6 percent of recurrent tumors.
In addition to identifying this previously hidden group of HER2-positive stem cells, further examination provided new insights into how these BCSCs maintain their resistance to treatment. A complex network of proteins, including HER2 and STAT3, modulate metastasis, programmed cell death and other functions. As a result, these cells survive the gamut of traditional anti-cancer therapies.
"We feel this research will have a major scientific, as well as clinical, impact," says Li. "We now have a better understanding of how BCSCs resist radiation and other treatments."
While recent research has shown that patients with HER2-negative breast cancer can indeed benefit from HER2 treatments, prior to this work no one understood the mechanisms. This research provides detailed confirmation that HER2 treatment can potentially improve outcomes in HER2-negative breast cancers.
In addition to opening up new treatment options for HER2-negative patients, the research also provides a diagnostic pathway. Markers, such as CD44, could help clinicians identify aggressive, HER2-positive BCSCs in cancers that are ostensibly HER2-negative, individualizing treatment to match each patient's needs. These findings may also advance treatment for other cancers.
"This may open the possibility of treating HER2-positive stem cells in bone, lung or brain cancers, which are all difficult to treat in the later stages," says Li.
Other authors were Nadire Duru, Ming Fan, Demet Candas, Cheikh Menaa, Hsin-Chen Liu, Danupon Nantajit, Kai Xiao, Angela Eldridge and Kit S. Lam, at UC Davis, Yunfei Wen at MD Anderson, Brett A. Chromy at UC Davis and Lawrence Livermore, Shiyong Li at Emory University, Douglas R. Spitz, Holden Comprehensive Cancer Center and Max S. Wicha at the University of Michigan Comprehensive Cancer Center.
This research was supported by the National Institutes of Health Grant CA133402, CA152313, and by the U.S. Department of Energy Office of Science Grant DE-SC0001271.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/vq_ZSMTRiiw/121214191514.htm
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I often tell my clients at iContact that they should think like a newspaper editor when building their email marketing campaigns. Despite the newspaper industry?s slide in fortunes in recent years, there is still plenty we can learn from the once great press barons.
John W. Hayes will be running a full-day workshop entitled?Becoming THE Expert: Content Marketing Boot Camp?in?London?on February 13th, 2013. Tickets for this event are extremely limited and can be?booked here.
photo: NS Newsflash
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I'm going to go out on a limb here, but my guess is if you went around and asked people in the startup community what they thought about Mike Maples at Floodgate, they would describe him as a sensible and successful entrepreneur turned investor and someone you'd most likely be thrilled to have on your team. In my personal opinion as an investor, I think he makes some pretty sound investment decisions. His previous bets include Modcloth, Chegg, CoTweet, Formspring and an early investment in Twitter.Source: http://feedproxy.google.com/~r/Techcrunch/~3/JjKv-sqGDq0/
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Join us on?December 24, 2012?at 2:00pm for?Barbed Wire, Barn, and a Baby!
This Christmas season, we would like to invite you to the annual?Christmas Eve at the Hardware Storeservice. If it sounds unconventional, it is! ?However, for several years now many in our community have gathered at Eagle Hardware on Christmas Eve and celebrated the birth of our Savior. This year will be no different! ?We would enjoy nothing more than your attendance. You are cordially invited to experience Christmas Eve like never before! ?While?Barbed Wire, Barn, & a Baby?on Christmas Eve at Eagle Hardware may not be your traditional Christmas Eve service, we promise it is the perfect way to?celebrate a meaningful, worshipful Christmas with family and friends.
Hope to see you there,
Shawn and Mary Risinger
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LONDON/BEIJING (Reuters) - China's vast manufacturing sector expanded in December but the euro zone is probably deeper in recession, business surveys suggested on Friday.
Data researcher Markit said its Euro zone Flash Composite Purchasing Managers Index, which combines both manufacturing and services sector data, showed small signs of improvement.
It rose to a nine-month high of 47.3 this month, beating forecasts for 46.8.
But this remains below the 50 mark that signifies contraction and Markit said the PMI data for the fourth quarter is consistent with a decline in overall growth of 0.5 percent.
China's data, however, may signal that the global economy is on the mend.
"The improved conditions on financial markets and the pick-up in global growth momentum, as signaled by the further pickup in the Chinese PMI, should steady the pace of decline from here on," said Martin van Vliet at ING.
China's manufacturing sector expanded in December at its fastest pace in 14 months as new orders and employment rose, adding to evidence of a pickup in the economy that helped to boost market sentiment.
"The renewed rise in the headline PMI is a further sign that the Chinese economy is already starting to recover," said Nikolaus Keis at UniCredit.
The HSBC flash PMI for December rose to 50.9, the highest level since October 2011 and the fifth straight monthly gain. A figure above 50 indicates that growth is accelerating, while one below 50 shows slowing growth.
Data due at 8:58 a.m. ET is expected to show manufacturing activity also expanded again this month in the United States, albeit at a slightly weaker pace than in November.
RAY OF LIGHT
The euro zone economy contracted 0.2 percent in the second quarter and 0.1 percent in the third, meeting the technical definition of a recession and a Reuters poll last week predicted a 0.3 percent contraction in the current period.
That would be slightly better than the PMIs suggest.
Earlier, composite PMI data from Germany, Europe's largest economy, showed its private sector bounced back to growth for the first time in eight months in December.
In neighboring France, however, while the downturn eased the PMI held below 50 for the 10th straight month.
The regional PMI has been below the 50 mark for all but one of the past 16 months but the euro zone agreed a deal on Thursday to provide nearly 50 billion euros in long-delayed aid to Athens.
It averts a catastrophic default and secures Greece's survival in the euro zone after months of doubt and political turmoil. Athens had repeatedly missed fiscal targets agreed with the EU and the International Monetary Fund, and stalled structural economic reforms.
The PMI for the euro zone's dominant service sector rose to 47.8 this month from 46.7, beating forecasts for a rise to 47.0.
The continued downturn came despite firms cutting prices despite their costs rising - cutting into their margins - for the ninth month.
Official data showed inflation in the bloc eased to 2.2 percent in November, potentially giving the European Central Bank room to ease policy further and support growth.
Manufacturers, who led the bloc out of the last recession, fared little better. The factory PMI crept up to 46.3 from 46.2, missing forecasts for a steeper rise to 46.6.
But in a further sign the global economy might be improving, the rate of decline in new export orders from factories eased, with the sub-index at a nine-month high of 46.8.
"There are some rays of hope here. It is moving in the right direction so there are signs that the business cycle has reached a low point globally and is picking up," Chris Williamson, chief economist at Markit said.
(Editing by Jeremy Gaunt.)
Source: http://news.yahoo.com/china-mend-euro-zone-still-shrinking-113555048--business.html
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Posted on December 13, 2012 by Cricinfo Live Scores
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Rene and Georgia share their favorite iPhone, iPad, and Apple gifts for the holidays, including iOS and Mac devices, accessories, and apps. This is the iMore show!
You can reach all of us on Twitter @iMore, or you can email us at podcast@imore.com or just leave us a comment below.
For all our podcasts -- audio and video -- including the iMore show, ZEN and TECH, Iterate, Debug, Ad hoc, and more, see MobileNations.com/shows
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Dec. 13, 2012 ? Cancer scientists led by Dr. John Dick at the Princess Margaret Cancer Centre have found a way to follow single tumour cells and observe their growth over time. By using special immune-deficient mice to propagate human colorectal cancer, they found that genetic mutations, regarded by many as the chief suspect driving cancer growth, are only one piece of the puzzle. The team discovered that biological factors and cell behaviour -- not only genes -- drive tumour growth, contributing to therapy failure and relapse.
The findings, published December 13 online ahead of print in Science, are "a major conceptual advance in understanding tumour growth and treatment response," says Dr. Dick, who holds a Canada Research Chair in Stem Cell Biology and is a Senior Scientist at University Health Network's McEwen Centre for Regenerative Medicine and Ontario Cancer Institute, the research arm of the Princess Margaret Cancer Centre. He is also a Professor in the Department of Molecular Genetics, University of Toronto. The research work was primarily carried out in Toronto by Antonija Kreso, Catherine O'Brien, and other members of the Dick lab with support from clinician-scientists at Mount Sinai Hospital and at the Ontario Institute for Cancer Research, and from genome scientists at St Jude Research Hospital, Memphis, and the University of Southern California, Los Angeles.
By tracking individual tumour cells, they found that not all cancer cells are equal: only some cancer cells are responsible for keeping the cancer growing. Within this small subset of propagating cancer cells, some kept the cancer growing for long time periods (up to 500 days of repeated tumour transplantation), while others were transient and stopped within 100 days. They also discovered a class of propagating cancer cells that could lie dormant before being activated. Importantly, the mutated cancer genes were identical for all of these different cell behaviours.
When chemotherapy was given to mice in which the human tumours were growing, the team made the unexpected finding that the long-term propagating cells were generally sensitive to treatment. Instead, the dormant cells were not killed by drug treatment and became activated, causing the tumour to grow again. The cancer cells that survived therapy had the same mutations as the sensitive cancer cells proving that cellular factors not linked to genetic mutation can be responsible for therapy failure.
The research challenges conventional wisdom in the cancer research field that the variable growth properties and resistance to therapy of cancer cells are solely based on the spectrum of genetic mutations within a tumour, says Dr. Dick. Instead, the scientists have validated a developmental view of cancer growth where other biological factors and cell functions outside genetic mutations are very much at play in sustaining disease and contributing to therapy failure.
The new research published builds on decades of experience by Dr. Dick, who focuses on understanding the cellular processes that maintain tumour growth. In 2004, Dr. Dick published related findings in leukemia, but in the present study his team was able to compare the importance of genetic events with cellular mechanisms for the first time. It is also the first study of its kind in a solid tumour system.
Dr. Dick says the findings convinced him that the conventional view that only explores gene mutations is no longer enough in the quest to accelerate delivery of personalized cancer medicine to patients -- targeted, effective treatments customized for individuals.
"The data show that gene sequencing of tumours to find the spectrum of their mutations is definitely not the whole story when it comes to determining which therapies will be most effective," says Dr. Dick.
"This is a paradigm shift that shows research also needs to focus on the biological properties of cells. For example, finding a way to put dormant cells into growth cycles could make them more sensitive to chemotherapy treatment. Targeting the biology and growth properties of cancer cells could expand the repertoire of usable therapeutic agents and provide better outcomes for patients."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/zR3XiDjZ43Y/121213142309.htm
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