CARSON, Calif. (AP) - Alvaro Saborio scored three goals as Real Salt Lake moved into second place in the Western Conference with a 4-0 win against Chivas USA on Saturday night.
Paulo Jr. also scored for Salt Lake (16-11-4), which took over sole possession of second in the West. Salt Lake began the day tied with idle Los Angeles and one point ahead of Seattle, which had a draw at Vancouver.
Chivas (7-16-7) remained last in the West after losing their sixth consecutive match and saw their scoreless streak reach a season-high 442 minutes.
Saborio scored two early goals to help give Salt Lake a 2-0 lead after 12 minutes. He completed his hat trick in the 65th minute when he hit the underside of the crossbar and saw the ball bounce over the goal line in the 65th minute.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Tampa, FL-- The owner of the Blow Bar in Tampa is raising money to bring a?hair saving?therapy for breast cancer patients to the Tampa Bay area.
Leslie Betts is raising money to buy?special freezers to store cold caps. Cold Cap Therapy is an experimental treatment used in Europe that helps breast cancer patients undergoing chemotherapy, save their hair.
The Cold Caps must be changed every half hour during treatment. The caps?keep the scalp cold?during chemo so the hair follicle is not damaged, and less likely to fall out.
See pictures of the experimental cold caps here
It is still awaiting FDA approval and some oncologists are skeptical about allowing it.
Leslie says women who have?used it have been lobbying for more cancer centers and oncologists in the Tampa Bay area?to offer it as part of treatment.
Cold Cap Therapy is not covered by insurance. The disposable caps cost roughly $1600 and the specialty freezer costs $2500.
Click here to learn more about the Rapunzel Project
Blow Bar Styling Salon is located at 310 South Dale Mabry Highway.
If you know an oncologist or cancer center that may be interested in Cold Cap Therapy, you can call Leslie at 813-876-2569.
First they invaded our factories, and now it's our hotel rooms. Is nowhere safe from the robots? In truth, Ibis' upcoming Sleep Art project is very slick, even if it smacks of robot voyeurism. Ibis hotels in Berlin, London and Paris will let 40 successful applicants sleep on beds that each have 80 sensors translating movements, sound and temperature into truly unique acrylic paintings by robotic arms connected through WiFi. You don't have to worry that the machines are literally watching you sleep -- there's no cameras or other visual records of the night's tossing and turning, apart from the abstract lines on the canvas. All the same, if you succeed in landing a stay in one of the Sleep Art hotel rooms between October 13th and November 23rd, you're a brave person. We all know how this ends.
Since the arrival of Apple's iPad, tablet computers have primarily remained consumption devices targeting consumers. However, at Thursday's formal launch of its new Atom processor, formerly known by the code name "Clover Trail," Intel showed off eight new devices geared for the enterprise.
ACCRA, Ghana (AP) ? A lawyer says the spokesman of Ivory Coast's former president was arrested Friday, just days after being released on bail after an extradition hearing.
Lawyer Lucie Bourtoumieux said Saturday her client, Justin Kone Katinan, was arrested for the second time on Friday. Bourtoumieux, who also represents former Ivory Coast President Laurent Gbagbo, said Ivory Coast President Alassane Ouattara's government had new "allegations of blood crimes" against her client.
Katinan, a registered asylum seeker in Ghana, was arrested in August after Ivory Coast issued an international warrant charging him with economic crimes.
Gbagbo is awaiting trial for crimes against humanity at the International Criminal Court at The Hague. His refusal to concede defeat to now President Ouattara in 2010 plunged the nation into months of violence, killing at least 3,000.
An anonymous reader writes with news of a recent paper about the bias among science faculty against female students. The study, recently published in the Proceedings of the National Academy of Sciences, asked professors to evaluate applications for a lab manager position. The faculty were given information about fictional applicants with randomly-assigned genders. They tended to rate male applicants as more hire-able than female applicants, and male names also generated higher starting salary and more mentoring offers. This bias was found in both male and female faculty. "The average salary suggested by male scientists for the male student was $30,520; for the female student, it was $27,111. Female scientists recommended, on average, a salary of $29,333 for the male student and $25,000 for the female student."
TOM McCAHILL SAYS: ?We Can Stop the Highway Slaughter!?
MI?s famed automotive authority proposes a gutsy, double-barreled safety program which would make a lot of people mad?but also save a lot of lives.
SPEED, illegal speed, is the Number One cause of highway deaths, according to the majority of the high-tinkling brass in the safety business. To this I say, ?Phooey.? Speed is a cause of highway deaths?but then, so is slow-driving. As I see it, there are four primary causes of our annual roadway slaughter: obsolete highways, Stone Age police practices, bad drivers and unsafe automobiles.
I don?t intend to waste much space talking about out-of-date, overcrowded highways that are real killers by themselves. A lot of people, from President Ike on down, have been working on that one. If everybody agrees with his proposal to spend 50 billion bucks and ten years of effort on the job, maybe we?ll have decent roads by the time your son Herman starts asking for the keys to the family crate. In the meantime, standard Federal highway laws would help somewhat to straighten out the 48-state confusion.
Today, in some cities, making a right turn on a red light is permitted (although this fact is not always posted) while across the border into the next state it?s possible to wind up in the clink for doing the same thing. Too many road signs cry ?Wolf!? when there?s no wolf around. By warning of steep grades and dips that don?t exist, or a ?Dangerous Crossing? that turns out to be a cowpath, they often cause drivers to be caught off base and unprepared when these conditions really do exist. Some sort of standard, nation-wide system of road markers and traffic regulations would help.
As for the Stone Age police practices I mentioned, we?re all familiar with the occasional crack-down drives against speeders, the get-tough vehicle inspections, the sneaky radar patrols and the drunks blowing into balloons. Sure, the police nail a few offenders and prevent a wreck or two with these stunts. But, because their thinking is largely out-of-date and unrealistic, the total effect is like trying to extinguish a raging forest fire with a glass of water. Take the matter of excessive speed, for instance.
Actually, one pinch-wary citizen doing 20 on a legal 50-mile-an-hour highway can cause more deaths than a truckload of hot rodders. The frustration Joe Slow builds up in the drivers behind him can and does cause sane men to take almost suicidal risks to pass after several miles of creeping along. Many states now have regulations against this type of slowpoking?but how many people do you know who have been arrested for driving too slow? I?ll bet you know plenty who have been pinched for speeding.
Another dangerous cause of accidents, too often ignored by speed-conscious cops, is overloading. A man who drives all week on business runs, with only himself in the car, rarely considers that when he adds three other guys to the load for a weekend fishing trip, he can?t pass cars with nearly as much room to spare as he did the day before. The extra weight of people or luggage may cut his pick-up speed in half.
Two of the worst traffic disasters ever recorded happened this year. One of the wrecks involved a small car packed with ten people. In the other smash-up, the death car was carrying twelve persons. If police had nabbed the drivers of those overloaded hearses before the accidents happened, they?d have accomplished a lot more good than they do by waiting for some guy to exceed the speed limit or jump a red light.
Poor highways and unrealistic policing are only two angles to the highway murder problem. Far more important, to my mind, are the two other major causes of traffic deaths: bad drivers and unsafe cars. In these two departments I have a double-barreled plan to offer which I am convinced could slash the death toll drastically. First let?s take the drivers.
In New York City it is possible to take your driving test in traffic near Sutton Place, a little-traveled road along the East River where you will never go faster than 25 miles an hour. If you make all the right-hand signals and don?t run over the inspector, you will most likely receive a driver?s license?a certificate which will permit you to travel the Penn Turnpike, where 70 mph is legal, and give you the right to drive in states where 100 mph is not frowned on too hard, such as the speedways near Detroit. That arm-waving test at eight miles an hour back in New York will do you a lot of good here if suddenly your car goes into a dry slide at 70 or better. You can end up awfully dead and still be within the legal speed limits?in fact, not violating any traffic law whatsoever.
The answer is obvious even to the dimmest wit. That license you get for arm-waving and for not running through a light should allow you to use the highways only within certin limitations. You shouldn?t be allowed on fast throughways during peak hours or ever allowed to drive as fast as someone holding a Senior License (for lack of a better name). In order to get a Senior License, the driver should be given a much more thorough examination on a Federal proving grounds and all inter-state licenses should be Federal, i.e. uniform.
The senior driver will have to prove that he can handle a car at high speed in an emergency situation prepared by the proving grounds examiners. He must demonstrate that he knows how to handle a skid or slide or even a high-speed blowout. He will be tested on wet pavement and ice conditions. He will be given an emotional stability test and a reaction-time test which will have to be repeated every other year. The test will be rough but only those who pass it should be allowed on the fast turnpikes and super roads. The Senior License driver will have a metal tag attached to his license plate to prove his right. If he goofs and gets caught driving as he shouldn?t, he is reduced to a Junior License driver until he passes a new test.
There is little difference between learning to drive well and flying. Today both are equally dangerous. Can you imagine the rhubarb that would result if you could get a pilot?s license with the same ease with which you can get a driving ticket in most states? If you could, roof insurance would go sky-high and your garden would be continually cluttered with dead bodies.
To put my licensing program over will take more political guts than I think we have in either party. But if we rated drivers like we do pilots, with only the experienced ones getting a commercial ticket, your chances of living longer would be a lot better.
And so we come to Part II of the McCahill Plan, the part involving unsafe cars. The cause of many accidents, and the most neglected, is the equipment naive owners are conned into buying. Regardless of what the ads say, all cars are not safe, and for a number of reasons. As most of you readers know, it is my job to test every make and model of car made in America and most of the popular imports. As I have been doing this for many years, I have seen the safety of some makes improve and in others I have seen it go down the drain. However, space being limited and I having no desire to spend the Christmas holidays fighting a trumped-up libel suit, I will just make the following statement:
There are a number of truly good, road-able automobiles made in America today. On the other hand, there are makes which, in my opinion, are real killers. Some of these actually scare hell out of me. In my time I have driven a few pretty miserable pieces of transportation. Oddly enough, it is possible (and I have one specific car in mind) to find two models of the same make that run the full gamut from safe to dangerous. One is a top-flight road car that can corner, hold the road and be kept under complete control under all circumstances. The other model, in this case more costly, is a real ax murderer.
I don?t believe there is a single designer or manufacturer today who enjoys building out-of-balance, dangerous vehicles. Why do they do it? As Harley Earl, vice-president in charge of General Motors styling, recently stated, American women are the principal influence in buying today?s automobiles. Most women are more concerned with luxury and comfort than they are with an automobile?s athletic prowess. All manufacturers know this and, in order to meet the competition from their fellow balloon builders, they have had to go overboard with mushy suspension, ridiculously low-pressured tires and out-of-balance chassis to get the rear passenger seats off the rear axles. Naturally, some cars have gone even further than others and, I am sorry to report, have proved to be very popular with the buyers.
Now, if some large foodstuff .manufacturer was silly enough to market a cereal that, let?s say, models I know of would undoubtedly fail. The models that pass would be given a Government Certificate of Approval. If, after the manufacturer?s model passed the test, he altered the suspension, steering or any other safety factor, his license to manufacture this particular model would immediately be lifted and the manufacturer would be subject to a huge fine. After the first year or two the requirements would be stricter so that within a short time every American car on the road would be much safer, under all conditions, than the finest cars we build today. This would offer a brand-new challenge to young engineers and any honest manufacturer should welcome such controls and be proud of his Government seal of approval.
In fairness to the manufacturers, the latest fad of blaming highway deaths on the so-called horsepower race is ridiculous. In many cases that extra horsepower is needed to get you safely around one of those railroad-car-long tractor-trailers on a two-lane highway (the world?s most dangerous type of road, in my opinion). In a pinch, a skilled driver will be a lot safer in a good car with 200 horsepower than he will in one with half that much moxie.
On the other hand, a little item like tire pressure can, under some conditions, mean the difference between living and dying. A car with 32 pounds of air often can be controlled in a semi-emergency situation where a car with factory-recommended pressure of 26 or 24 pounds will mush, plow and become completely unmanageable. Actually, a car with tires inflated to factory specifications? even the finest car we make today?could not get around my test course for safe roadability!
I have demonstrated this to some manufacturers on their own proving grounds by beating some of their latest and much more powerful equipment by simply putting more air in the tires of the earlier model I was driving. All company engineers know these facts but they have been cut short in their tracks for years by their own sales and advertising departments who, with a pat on the head, say, ?Now, now, Junior, we know what sells automobiles?build them our way!?
My proposed Government Certificate of Approval should also be required for the manufacturer of component parts and accessories. The parts manufacturer, as well as the automobile producer, has a definite duty to the innocent buyer which has been neglected for some time. Many of these off-beat items can easily cause death to the unsuspecting motorist. One important example is out-of-round, or off-balanced tires. The number of untrue automobile tires sold to the consumers, and to automobile companies, would curl the hair of the most dyed-in-the-wool pessimist. Many of these tire faults can be corrected to some degree through wheel balancing?but the manufacturers never warn the buyer about this necessary check. In my opinion, if you were fortunate enough to buy a new car with five really round, thoroughly-balanced tires today, it would come pretty close to being a miracle. On my own Lincoln, when I went to have the spare tire balanced, the thoroughly honest wheel technician refused to do it. After testing it he said the tire itself was so far out of true that it would be impossible to get it anywhere near right without adding enough lead weights to sink a small rowboat.
Why is this tire stuff so important? When a tire is out of balance, the way my spare was, it develops a gyroscopic action whose intensity increases with speed. At 100 mph a real dog of a tire can almost tear the wheel off the axle, the eccentric action is so severe. At any speed above 60 the car with unbalanced wheels can become extremely uncontrollable and, in some cases, will actually develop a galloping tendency. If you have to brake hard, the offbeat wheel motion makes it almost impossible to hold the car on a straight line.
If shotgun shells sold on the open market frequently blew up good guns and hurt the shooters, Uncle Sam would step in and investigate. To my knowledge, no one checks automobile tires to make sure they are in round. That?s one of the items that would be checked at my Federal proving grounds. There are lots of others.
For example, inspectors would check the hypnotic effect caused by air conditioning and too many automatic accessories designed to make driving as effortless as possible. I have driven some of these fully-loaded cars on turnpikes where I really had to concentrate to keep from taking a little snooze. With a soothing air-conditioned temperature inside the car lulling my senses and almost eliminating outside road or engine noises, and with automatic steering requiring no effort to navigate the barge?what a spot for 30 winks!
A Government-operated track and proving ground, where every model of car manufactured in America would be subjected to the impartial scrutiny of experts, would save thousands of lives every year. Combined with a realistic, hard-boiled Federal licensing system for drivers, safer roads and a modern system of police regulations, it could certainly reduce the death rate by more than half. A few Teddy Roosevelt-type politicians with guts enough to act could put such a program into effect.?Tom McCahill
A federal court of appeals has ruled that when a student with disabilities moves out of state, that doesn't absolve a school district from providing compensatory education services.
In a ruling this month in D.F. vs. Collingswood Borough Board of Education, the Third Circuit Court of Appeals reversed a previous ruling that excused the New Jersey school district from making up for special education services a student missed when enrolled in that district.
D.F. was a kindergartner in the district in the 2008-09 school year, but he had already been identified as having a disability by another school district. Midway through the school year, D.F.'s mother filed a due process complaint, alleging that the district wasn't upholding all of its obligations to her son under the Individuals with Disabilities Education Act. Over the course of the following school year, D.F.'s mother and the school district tussled over whether the boy should attend an out-of-district school. By the end of the 2009-10 school year, the family had moved to Georgia. An administrative law judge dismissed the case as moot.
The student's mother complained that her son had been in a regular classroom without a personal aide for the first half of the school year, violating his education plan and that he had been subjected to discipline without consideration of the fact that his behavior was a manifestation of his disability, among other issues.
D.F. had been diagnosed as having ADHD, oppositional defiant disorder, and although his cognitive abilities were at or above grade level, he threw objects, hit classmates, had temper tantrums, and ran away. In the school district where he was diagnosed with disabilities, strategies outlined in a behavior intervention plan had begun to improve his behavior.
The court ruled that there is "no basis to distinguish between out-of-district, but in-state, moves and out-of-state moves in the IDEA or in case law" and rejected the school district's theory that compensatory educational services were "subsumed within the education that he was currently receiving" from his new school district.
The Third Circuit said a "claim for compensatory education is not rendered moot by an out-of-district move, even if that move takes the child out of state," and said that to hold otherwise would undermine the purpose of IDEA and would disproportionately affect low-income families, who cannot afford to front the costs of their children's education.
The Education Law Center in New Jersey, which filed an amicus brief supporting D.F., said it was satisfied with the ruling.
It was "a simple matter of fairness" and a case that will "aid all students with disabilities in New Jersey and beyond," said Ruth Lowenkron, the senior attorney at the center who worked on the case.
But what does the ruling mean for Collingswood? The court said one way the district could provide this compensatory education is by establishing a fund that could be spent on D.F.'s education. The district could also pay D.F.'s new district or to contract with a local provider in his new home to provide tutoring, counseling, or other support services.
It seems like no matter how many ways you try to make your marketing more effective, you end up overlooking something. If you try too hard to achieve perfection, you?ll end up neglecting some crucial action steps. If you make a mistake, it?s not the end of the world so don?t worry about this too much. If you keep the principles we?ll be discussing in this article in mind, you?ll find it easier to succeed with your business blog.
Some blogs are so thick with advertisements, pop-ups and the like that you can hardly find the articles. You can understand the motivation behind this, but it?s annoying all the same. Remember that for your blog to be successful, you have to make it user friendly for your visitors. So just remember to only use the minimum number of plugins so you avoid a slow loading blog. At the same time, you shouldn?t use too many apps as they can also slow things down. You should have some kind of tracking script in place for analytics and data gathering. The cleaner your blog is, though, the more visitor friendly it will be.
Having a list of tasks you must complete every day is a simple but very helpful method that can be at the foundation of your time management plan. It doesn?t matter if you write it on a bulletin board or have it on a file on your laptop or phone as long as you have it handy. If you have dozens of things to do every day, this list can prevent you from forgetting something important. There are many ways to get distracted, either by other business related tasks or your personal life. There are, however, certain actions that are essential for you to complete every day. One task that is necessary for your business?s future growth is constantly finding new prospects or leads. This means getting steady traffic to your website, which is an ongoing challenge.
Online marketers, probably more than any other type of business owner, tend to find themselves multitasking a great deal of the time. You are drawn to the idea of multiple streams of income, perhaps in several different niches. What this usually does, however, is make it hard for you to give your full concentration on any single project. This is not the way to run a successful business. It?s more efficient to focus on one task at a time. If it is a major project, then work on that in addition to your daily business and marketing tasks. But do some load shedding and give yourself a break and room to focus on something.
Discussing this topic usually takes quite a while, as you can see based upon the length of this article. This article has not even scratched the surface about what can be said. No matter what your goals are, personal issues will always make or break your attempts to succeed with IM, no matter what type of business you set up. When it comes to your Internet business, realize that issues like this are par for the course when searching for online success.
It really is crucial to take things found at satelite direct into mind!
Hopkins researchers solve key part of old mystery in generating muscle massPublic release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Catherine Kolf ckolf@jhmi.edu 443-287-2251 Johns Hopkins Medicine
Implications for treating muscular dystrophy and other muscle wasting diseases
Working with mice, Johns Hopkins researchers have solved a key part of a muscle regeneration mystery plaguing scientists for years, adding strong support to the theory that muscle mass can be built without a complete, fully functional supply of muscle stem cells.
"This is good news for those with muscular dystrophy and other muscle wasting disorders that involve diminished stem cell function," says Se-Jin Lee, M.D., Ph.D., lead author of a report on the research in the August issue of the Proceedings of the National Academy of Sciences, and professor of molecular biology and genetics at the Johns Hopkins University School of Medicine.
Muscle stem cells, known as satellite cells, reside next to muscle fibers and are usually dormant in adult mammals, including humans. After exercise or injury, they are stimulated to divide and fuse, either with themselves or with nearby muscle fibers, to increase or replace muscle mass. In muscle wasting disorders, like muscular dystrophy, muscle degeneration initially activates satellite cells to regenerate lost tissue, but eventually the renewal cycle is exhausted and the balance tips in favor of degeneration, the researchers explain.
Muscle maintenance and growth under healthy, non-injury conditions have been more of a mystery, including the role of myostatin, a protein secreted from muscle cells to stop muscle growth. Blocking myostatin function in normal mice causes them to bulk up by 25 to 50 percent. What is not known is which cells receive and react to the myostatin signal. Current suspects include satellite cells and muscle cells themselves.
In this latest study, researchers used three approaches to figure out whether satellite cells are required for myostatin activity. They first looked at specially bred mice with severe defects in either satellite cell function or number. When they used drugs or genetic engineering to block myostatin function in both types of mice, muscle mass still increased significantly compared to that seen in mice with normal satellite cell function, suggesting that myostatin is able to act, at least partially, without full satellite cell function.
Second, the researchers guessed that if myostatin directly inhibits the growth of satellite cells, their numbers should increase in the absence of myostatin. The researchers marked the satellite cells with a permanent dye and then blocked myostatin activity with a drug. Mouse muscle mass increased significantly as expected, but the satellite cells did not increase in number, nor were they found fusing with muscle fibers at a higher rate. According to Lee, these results strongly suggest that myostatin does not suppress satellite cell proliferation.
Third, to further confirm their theory that myostatin acts primarily through muscle cells and not satellite cells, the team engineered mice with muscle cells lacking a protein receptor that binds to myostatin. If satellite cells harbor most of the myostatin receptors, removal of receptors in muscle cells should not alter myostatin activity, and should result in muscles of normal girth. Instead, what the researchers saw was a moderate, but statistically significant, increase in muscle mass. The evidence once again, they said, suggested that muscle cells are themselves important receivers of myostatin signals.
Lee notes that, since the results give no evidence that satellite cells are of primary importance to the myostatin pathway, even patients with low muscle mass due to compromised satellite cell function may be able to rebuild some of their muscle tone through drug therapy that blocks myostatin activity.
"Everybody loses muscle mass as they age, and the most popular explanation is that this occurs as a result of satellite cell loss. If you block the myostatin pathway, can you increase muscle mass, mobility and independence for our aging population?" asks Lee. "Our results in mice suggest that, indeed, this strategy may be a way to get around the satellite cell problem."
###
Authors on the paper include Se-Jin Lee, Thanh Huynh, Yun-Sil Lee and Suzanne Sebald from The Johns Hopkins University, Sarah Wilcox-Adelman of Boston Biomedical Research Institute, Naoki Iwamori and Martin Matzuk of Baylor College of Medicine, and Christoph Lepper and Chen-Ming Fan from the Carnegie Institution for Science.
This work was supported by grants from the NIH Office of the Director (DP5OD009208), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059685, R01AR060636, R01AR060042), the National Institute of Neurological Disorders and Stroke (P01NS0720027), the National Institute of Child Health and Human Development (R01HD032067) and the Jain Foundation.
Disclosure: Under a licensing agreement between Pfizer, Inc. and The Johns Hopkins University, S.-J.L. is entitled to a share of royalty received by the University on sales of products related to myostatin. The terms of this arrangement are being managed by the University in accordance with its conflict of interest policies.
On the Web:
Link to article: http://www.pnas.org/content/109/35/E2353.full?sid=285bad8c-d4b6-47f8-bd29-3924df68789c
Lee lab: http://www.jhu.edu/sejinlee/
Johns Hopkins Medicine
Media Relations and Public Affairs
Media Contacts: Catherine Kolf; 443-287-2251; ckolf@jhmi.edu
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Hopkins researchers solve key part of old mystery in generating muscle massPublic release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Catherine Kolf ckolf@jhmi.edu 443-287-2251 Johns Hopkins Medicine
Implications for treating muscular dystrophy and other muscle wasting diseases
Working with mice, Johns Hopkins researchers have solved a key part of a muscle regeneration mystery plaguing scientists for years, adding strong support to the theory that muscle mass can be built without a complete, fully functional supply of muscle stem cells.
"This is good news for those with muscular dystrophy and other muscle wasting disorders that involve diminished stem cell function," says Se-Jin Lee, M.D., Ph.D., lead author of a report on the research in the August issue of the Proceedings of the National Academy of Sciences, and professor of molecular biology and genetics at the Johns Hopkins University School of Medicine.
Muscle stem cells, known as satellite cells, reside next to muscle fibers and are usually dormant in adult mammals, including humans. After exercise or injury, they are stimulated to divide and fuse, either with themselves or with nearby muscle fibers, to increase or replace muscle mass. In muscle wasting disorders, like muscular dystrophy, muscle degeneration initially activates satellite cells to regenerate lost tissue, but eventually the renewal cycle is exhausted and the balance tips in favor of degeneration, the researchers explain.
Muscle maintenance and growth under healthy, non-injury conditions have been more of a mystery, including the role of myostatin, a protein secreted from muscle cells to stop muscle growth. Blocking myostatin function in normal mice causes them to bulk up by 25 to 50 percent. What is not known is which cells receive and react to the myostatin signal. Current suspects include satellite cells and muscle cells themselves.
In this latest study, researchers used three approaches to figure out whether satellite cells are required for myostatin activity. They first looked at specially bred mice with severe defects in either satellite cell function or number. When they used drugs or genetic engineering to block myostatin function in both types of mice, muscle mass still increased significantly compared to that seen in mice with normal satellite cell function, suggesting that myostatin is able to act, at least partially, without full satellite cell function.
Second, the researchers guessed that if myostatin directly inhibits the growth of satellite cells, their numbers should increase in the absence of myostatin. The researchers marked the satellite cells with a permanent dye and then blocked myostatin activity with a drug. Mouse muscle mass increased significantly as expected, but the satellite cells did not increase in number, nor were they found fusing with muscle fibers at a higher rate. According to Lee, these results strongly suggest that myostatin does not suppress satellite cell proliferation.
Third, to further confirm their theory that myostatin acts primarily through muscle cells and not satellite cells, the team engineered mice with muscle cells lacking a protein receptor that binds to myostatin. If satellite cells harbor most of the myostatin receptors, removal of receptors in muscle cells should not alter myostatin activity, and should result in muscles of normal girth. Instead, what the researchers saw was a moderate, but statistically significant, increase in muscle mass. The evidence once again, they said, suggested that muscle cells are themselves important receivers of myostatin signals.
Lee notes that, since the results give no evidence that satellite cells are of primary importance to the myostatin pathway, even patients with low muscle mass due to compromised satellite cell function may be able to rebuild some of their muscle tone through drug therapy that blocks myostatin activity.
"Everybody loses muscle mass as they age, and the most popular explanation is that this occurs as a result of satellite cell loss. If you block the myostatin pathway, can you increase muscle mass, mobility and independence for our aging population?" asks Lee. "Our results in mice suggest that, indeed, this strategy may be a way to get around the satellite cell problem."
###
Authors on the paper include Se-Jin Lee, Thanh Huynh, Yun-Sil Lee and Suzanne Sebald from The Johns Hopkins University, Sarah Wilcox-Adelman of Boston Biomedical Research Institute, Naoki Iwamori and Martin Matzuk of Baylor College of Medicine, and Christoph Lepper and Chen-Ming Fan from the Carnegie Institution for Science.
This work was supported by grants from the NIH Office of the Director (DP5OD009208), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059685, R01AR060636, R01AR060042), the National Institute of Neurological Disorders and Stroke (P01NS0720027), the National Institute of Child Health and Human Development (R01HD032067) and the Jain Foundation.
Disclosure: Under a licensing agreement between Pfizer, Inc. and The Johns Hopkins University, S.-J.L. is entitled to a share of royalty received by the University on sales of products related to myostatin. The terms of this arrangement are being managed by the University in accordance with its conflict of interest policies.
On the Web:
Link to article: http://www.pnas.org/content/109/35/E2353.full?sid=285bad8c-d4b6-47f8-bd29-3924df68789c
Lee lab: http://www.jhu.edu/sejinlee/
Johns Hopkins Medicine
Media Relations and Public Affairs
Media Contacts: Catherine Kolf; 443-287-2251; ckolf@jhmi.edu
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
IOWA CITY, Iowa (AP) ? In the weeks before Election Day, University of Iowa students will have a dozen places on campus to vote for President Barack Obama or challenger Mitt Romney.
Residents in the heavily Latino city of Denison will be able to cast ballots at a Mexican grocery store. Those living in the Republican-leaning Des Moines suburbs will get to vote early at evangelical churches. And voters in the state's most conservative county, Sioux, will be able to make their picks at a small-town library.
Iowa is one of 32 states that allow early voting, and both presidential campaigns are trying to take advantage of an unusual state law that gives political supporters a big say in where the ballots are cast. As voting begins Thursday, the sudden profusion of conspicuously Obama-friendly or Romney-friendly polling places in this key battleground state will serve as a novel example of how the trend toward flexibility is morphing the tenets of Election Day across the nation.
Iowa's law allows anyone who gets the signatures of 100 county voters to choose a specific voting place in that county. Election officials must hold balloting at that site for at least one day in the 40 days before the Nov. 6 election. The law is apparently the only one of its kind in the nation, said Jennie Bowser, who tracks election law at the National Conference of State Legislatures.
Both campaigns filed a batch of petitions before last week's deadline calling for satellite voting at locations carefully chosen to make it as easy as possible for their backers to vote.
"This is substantially more than we had in the last presidential," said Tim Box, an elections administrator in Linn County, the state's second-largest, which received 12 petitions from the campaigns. He is preparing to operate sites at a union hall, on three college campuses and at an African-American church in response to Obama campaign petitions and at Lutheran churches where voting was sought by Romney's backers.
Obama campaign spokeswoman Erin Seidler said the campaign is using the polling place petitions to target key parts of the electorate Obama needs to win: college students, Latinos in small towns and African-Americans in bigger cities.
"We are strategic in how we are reaching out to voters," she said.
Romney campaign spokesman Shawn McCoy said the GOP is also spotting polling places "so that more Iowans have an opportunity to voice their support for Gov. Romney."
In most states that allow early voting, state laws direct local election administrators to choose the polling places. They typically favor neutral sites that are accessible for the general public such as libraries and courthouses, as do Iowa officials when they pick locations on their own.
Iowa's petition law was passed decades ago to allow residents to seek early voting in counties where officials refused to set up satellite sites. But as early voting became more popular, partisans have increasingly gamed the process in a way that critics say calls fairness into question. About 35 percent of Iowa voters cast ballots before Election Day in 2008, above the national average of 30 percent.
"It's partisan chaos, which ought not to happen," said Doug Lewis, executive director of the Election Center, a nonprofit organization in Houston that trains election officials on best practices. "I can't fault the campaigns for figuring out the weaknesses in the law and therefore capitalizing on it. But what that does for Iowa is it gives the election a skewed process."
The practice increased in 2010 and could intensify this cycle. In the midterm election, Republicans collected petitions for polling places at evangelical churches in Ames; two churches even opened polls during Sunday services, sparking criticism from the American Civil Liberties Union. Officials in Johnson County, a liberal stronghold that's home to the University of Iowa, operated a record 27 petition-requested sites in 2010.
This year, Johnson County Auditor Tom Slockett received a similar deluge of petitions seeking sites at the university's law school, residence halls, student union, main library and more. The influx of petitions has worried local elections officials, who say they cause last-minute logistical and budgeting headaches.
"I have long felt that the bar is too low to request satellite sites," said Slockett, recalling he was once forced to host a site on the stairwell of an academic building, the only place where voting could be set up. But attempts to change the law to make it harder to petition have failed.
In Black Hawk County, Democrats petitioned to open six sites on the University of Northern Iowa campus in Cedar Falls and one site at a black church in Waterloo. Republicans petitioned for voting at the American Martyrs Retreat House, which is operated by the Catholic Church, in rural Union township. The number of petitions is up significantly from four years ago, county elections manager Kyle Jensson said.
"We'll be scurrying to so many places," Jensson said.
In Denison, a city of 8,300 in western Iowa that is more than 40 percent Latino, the Obama campaign petitioned to require voting at La Jalisciense Tienda grocery store and in an empty former Mexican restaurant. Crawford County Auditor Terri Martens said she worried that non-Latinos who do not shop or eat at those locations wouldn't feel comfortable voting there.
"It seems like the purpose that this group is using it for is to yank one sector of the public out of the voting crowd and make it ultra-convenient for them," Martens said. "My job is to make it convenient for all voters. I'm having a difficult time with this."
Martens said she was also frustrated with the tactics the Obama operatives used to secure voting at locations they wanted.
"It was, 'If you do this and you guarantee us these days, we won't file any more petitions,'" she recalled. "I was like, 'Come on.' It was disappointing as a registered Democrat myself."
From a birth control costume to a sign that read "Voting Vagina," it was pretty clear why participants of a voters' rally outside a Todd Akin fundraiser thought the U.S. Senate candidate was the wrong man for the job
"It's disgusting we have a congressman who doesn't understand science," said LaDonna Appelbaum, of Creve Couer. "We need women making decisions for women, not men."?
Protesters lined the street of South Kirkwood Road outside Woodbine Center near Trattoria Branica?where Akin was holding a fundraising event after a press conference at the Kirkwood Train Station.?
Many protesters wore pink Planned Parenthood T-shirts. The St. Louis chapter of Advocates of Planned Parenthood mobilized supporters of the organization through an email listserve.?
"We're here because we don't think (Akin) is right for Missouri," said Alison Gee, Vice-President of Public Policy for Advocates of Planned Parenthood-St. Louis Region (PPSLR).?
Gee said Akin's comment on Fox 2 that referenced "legitimate rape" was not specifically the reason for the presence of PPSLR at the protest. Instead, it was Akin's record on women's health issues as a whole.
"His record stands for itself," she said.
The voter rally drew men who were equally concerned about Akin's stance on reproductive rights and women's health issues.
"He's threatening the rights of half of Americans," said Scott Callaghan, of Kirkwood. "It's our duty to stand up for a group even if you're not affected."
Although women's health was the primary concern of protesters, it was not the only issue that brought voters to South Kirkwood Road Monday.
David Meinell, of St. Charles, and Judith Parker, of Des Peres, said they did not support Akin's opposition to the Affordable Health Care for America Act and feared retired residents would suffer if Akin was elected.
Patricia Schuba, of West Chesterfield, disagrees with Akin on environmental issues.?"It's possible to have great jobs and a clean environment," she said.
As motorists drove by the demonstration, some gave encouraging honks that met with cheers from protesters. The group planned to stay at the strip of South Kirkwood Road until the fundraising event was underway.?
Exercise has been recognized for a long time that it will cause you to be healthier. This is true and particularly among men. Working out comes with many returns while causing tiny side effects for optimumMen?s Health.?Before you start to think of the terrible exercise program you might associated with once been on, this is the new look at the reason why men need to get some exercise regularly.Exercising can not
just help you, but other folks around you. If you sit around all day without having to burn any energy, males can become moody, irritable or just plain nasty.A short workout
can get rid of everyday anxiety, or at least make it easier and never affect you in which your friends and family want not do with you. Training can help your interactionsin every way.?
Men like to get into the routine of points and live a daily schedule, not modifying too much from day to day. One of the benefits of exercising every day before work is that you willactually have energy.?
Immediately after your workout you may feel a bit tired, yet all that movement merely woke up the body and is also now prepared for other day. The same worn out feeling you have after an intense workout is totally different from fatigue towards the coreday.Exercising
absolutely improves strength and also endurance. When this happens, it makes living everyday life easier. If you do a lot of strolling in your workplace or perhaps need to go up lots of stairs, the extra strength you will get by exercising you can getthrough the day.?
There are many experts that have established that exercise really can fight off diseases or at best slow down the process. A number of the diseases that can be stopped are heart disease, osteo-arthritis, muscle mass loss, strokeand high blood pressure.?
Considering that exercise also beefs up your muscles and joint parts, aging can take longer since your body can be in optimal health. Vulnerable muscles, bones and especially heart will make getting oldermore progressive.?
Training can boost up your immune system as well. Exactly like fighting off diseases, doing exercises can be extremely effective towardseveryday colds.?
Workout also produces a much more resilient heart. The heart can be a major muscle which is important to keep it solid. If you are not fit, when you do exercise, or perhaps climb stairs, you can feel the heart doing workextra hard.?
Per week of exercise you devote, you are slowly increasing your heart muscle mass and in time, precisely what feels like a struggle now will soon be done quickly.The whole cardiovascular system
will certainly function more productively, creating a stronger push for blood flow both to and fromthe heart.Weight problems
are probably the main reasons men plan to exercise regularly. One thing to mention is that although losing weight through exercise is the most helpful, exercising is more about health and fitness your body and strengthening your muscles, joints along with ligaments and cardiovascular.
Typically, when OEMs launch the next generation of their mobile wares, we're treated to painstakingly choreographed industry parties (that we chronicle in great detail). In fact, we can think of a recent one in particular that saw several tech journos corralled into a blue-hued freight elevator and then let loose on three levels of demos. Well, if you thought new product excitement began and ended with select press events or that executive-level enthusiasm was all just a by-product of intense media training, think again. As you can see from the image above, lunch time at Nokia's glass-walled HQ saw a crowd of curious employees noshing on the assortment of cafeteria delights while also sampling the newly announced Asha 308 and 309. It's that company-wide, inside-out passion for all things Nokia we've seen evidence of again and again throughout our time in Espoo. And because of that, we feel justified in saying there's clearly something in the Finnish water.
After we store online for low price electronic devices, we shop for whatever from laptops to mobile telephones. How do you recognize which you are becoming the most effective deal? What are the best areas to buy on the web when shopping for cheap consumer electronics? People desire to get monetary savings on electronic devices, but you should not know the way to do it and in which to shop for some excellent promotions. Pay out consideration intently, while you are about to learn the essentials of purchasing for inexpensive on the web consumer electronics.
The initial matter you?ll want to know may be the regular worth on the products you are purchasing. If it is newer style of large tech gadget, then it?s most likely to get slightly bit pricier, primarily much more so than something which continues to be all around for your extended quantity of time. Do your investigation on the wished-for product or service you wish to uncover and just how significantly it normally goes for around the common market. Look your solution up on several various websites and contact a few of merchants that might have it on their shelves. Make sure you assess charges in the least from the places which you check. Try and do just as much study as you possibly can before you make a choice.
In many cases, auction web sites such as Amazon or eBay are really great web sites for locating deal specials on consumer electronics since you are able to bid within the expense and fork out only anything you want for it. If your price gets also higher, you need to do not should bid on it. There are actually numerous other areas in addition to cyberspace which you can come across price reduction bargains on higher high-quality electronic devices such as pawn stores and local thrift merchants. You?ll be very impressed at everything you can uncover for those who arrive early sufficient before the group of deal hunters get there. Garden sales and flea markets are also a different excellent destination to try to find affordable consumer electronics. Liquidation sales for merchants heading from business enterprise certainly are a wonderful supply for saving on household electronic devices.
Some items to stop when deal hunting for electronics is supplying into regular store costs. Some sales and profits associates will endeavor to converse you into buying something which is way as well high that you should manage, and who can blame them? They are just undertaking their work opportunities. It isn?t hurting them that you are having to pay a huge selection of bucks extra for one thing you?ll be able to find a lot more affordable. Never allow income people who find themselves just ?doing their jobs? get advantage of you. In case you know somebody who owns a pc retail outlet, then look at inquiring them from what wholesale distributor do they order their electronic devices. By carrying out this, you may possibly preserve countless numbers within a calendar year or more.
The stated expense on an digital product isn?t constantly the value that you simply really have to pay out. When you recognize that the price is simply way too large on the particular electronic, consider stating to your profits connect or keep proprietor which you would like to buy a unique merchandise, but only if the price is dropped to your decreased charge. You?ll be surprised at the amount individuals will do the job to make sure you you as being a purchaser, recognizing that you?ll return for potential purchases inside the foreseeable future. Bottom line ? Usually do not allow revenue folks consider benefit of you or seek to tell you in the event you really don?t invest in the merchandise now, it will be gone tomorrow. There may be a much better, more cost-effective way.
Previous, although not the very least you are going to wind up conserving by yourself a fortune after you stumble into your gold mine of low price consumer electronics. Be individual and arm oneself with the knowledge with everything you want, anything you are willing to pay for, and adhere towards the finances you set on your own. Not only will you might have the newest and most affordable great tech excellent devices, but you will also be capable to utilize the hundreds or even 1000?s of pounds still left more than for your other points in the lifestyle that you simply want. With all the economic climate wanting like it?s right now, we want each of the saving, budgeting, and bargaining that we can stand. So no matter if you?re looking for your most current technological innovation to accomplish the home place of work, or are purchasing a model new property laptop for yourself, husband or wife, or relative, seeking a deal is often a need to in the present culture. When a discount has long been discovered, the feeling truly is priceless.
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They have signed a joint working agreement to develop R+D projects for environmental prevention and recovery at sea and on the coast
This press release is available in Spanish.
AZTI-Tecnalia, the Basque technological centre specialising in marine and food research, has signed a joint working agreement with the China Academy of Environmental Sciences to develop R+D projects for environmental prevention and recovery at sea and on the coast. The agreement is a further example of AZTI-Tecnalia as an international technological centre of reference.
On the occasion of the visit to the AZTI-Tecnalia installations by the President of the China Academy of Environmental Sciences, accompanied by representatives of various research centres and universities dependant on this institution, a joint working agreement was signed by the two bodies. The agreement is one more step in the commitment by the Chinese Government to find solutions to the environmental implications of the rapid industrial development their country is undergoing. In order to reduce the effects that this growth is having, they have drawn up a framework programme for environmental protection and, being at its implementation stage, they have sought the collaboration and experience of international organisations of reference. This agreement can open opportunities for co-operation in the future for other Basque institutions and businesses interested in the environmental economy in China.
AZTI-Tecnalia will provide the China Academy of Environmental Sciences, and the various research centres that the institution has along the coast of the Asian country, with its technology, tools, methods of study and know-how in coastal and marine environment matters, the goal being to achieve sustainable development for the Asian country. AZTI-Tecnalia will collaborate with managers of the Chinese Government in order to take the most appropriate decisions in each case and achieve better protection for its coasts and seas. The collaboration is fundamentally focused on two spheres: research applied to sustainable coastal development and the observation, analysis and prediction of the behaviour of the sea. Training and personnel interchange is also planned, with various annual seminars to be held in China.
Amongst the activities that AZTI-Tecnalia and the Academy of Environmental Sciences of China propose undertaking is the incorporation of real-time monitoring systems for marine processes. The aim of this is to gather data in an ongoing manner in order to be able to assess current behaviour and predict the future behaviour of the sea and the estuaries, in such a way that the impact of human action on the sea and the coast can be managed and evaluated in the most appropriate way. AZTI-Tecnalia already has experience in monitoring the sea thus, thanks to the Kostasystem project, implemented locally at various beaches in the Basque Country and also in the Canary Islands.
This environmental monitoring of the sea and the estuaries will also be undertaken with sampling stations for measuring water quality and with the measurement of the currents, tides and waves. Another planned action is the development of methods for the evaluation of environmental impact, especially with reference to human activities, such as public works along the coast and marine energy infrastructure.
Use of Azti's Marine Biotic Index in China
The marine authorities in China are currently studying the possibility of officially employing a tool created by AZTI-Tecnalia for evaluating the ecological state of the quality of the sea and the estuaries. This is AMBI (the Azti Marine Biotic Index), software that contains data on more than 6,000 species throughout the planet, and which has had great repercussion and use worldwide.
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AZTI-Tecnalia to collaborate with China Academy of Environmental Sciences Public release date: 24-Sep-2012 [ | E-mail | Share ]
They have signed a joint working agreement to develop R+D projects for environmental prevention and recovery at sea and on the coast
This press release is available in Spanish.
AZTI-Tecnalia, the Basque technological centre specialising in marine and food research, has signed a joint working agreement with the China Academy of Environmental Sciences to develop R+D projects for environmental prevention and recovery at sea and on the coast. The agreement is a further example of AZTI-Tecnalia as an international technological centre of reference.
On the occasion of the visit to the AZTI-Tecnalia installations by the President of the China Academy of Environmental Sciences, accompanied by representatives of various research centres and universities dependant on this institution, a joint working agreement was signed by the two bodies. The agreement is one more step in the commitment by the Chinese Government to find solutions to the environmental implications of the rapid industrial development their country is undergoing. In order to reduce the effects that this growth is having, they have drawn up a framework programme for environmental protection and, being at its implementation stage, they have sought the collaboration and experience of international organisations of reference. This agreement can open opportunities for co-operation in the future for other Basque institutions and businesses interested in the environmental economy in China.
AZTI-Tecnalia will provide the China Academy of Environmental Sciences, and the various research centres that the institution has along the coast of the Asian country, with its technology, tools, methods of study and know-how in coastal and marine environment matters, the goal being to achieve sustainable development for the Asian country. AZTI-Tecnalia will collaborate with managers of the Chinese Government in order to take the most appropriate decisions in each case and achieve better protection for its coasts and seas. The collaboration is fundamentally focused on two spheres: research applied to sustainable coastal development and the observation, analysis and prediction of the behaviour of the sea. Training and personnel interchange is also planned, with various annual seminars to be held in China.
Amongst the activities that AZTI-Tecnalia and the Academy of Environmental Sciences of China propose undertaking is the incorporation of real-time monitoring systems for marine processes. The aim of this is to gather data in an ongoing manner in order to be able to assess current behaviour and predict the future behaviour of the sea and the estuaries, in such a way that the impact of human action on the sea and the coast can be managed and evaluated in the most appropriate way. AZTI-Tecnalia already has experience in monitoring the sea thus, thanks to the Kostasystem project, implemented locally at various beaches in the Basque Country and also in the Canary Islands.
This environmental monitoring of the sea and the estuaries will also be undertaken with sampling stations for measuring water quality and with the measurement of the currents, tides and waves. Another planned action is the development of methods for the evaluation of environmental impact, especially with reference to human activities, such as public works along the coast and marine energy infrastructure.
Use of Azti's Marine Biotic Index in China
The marine authorities in China are currently studying the possibility of officially employing a tool created by AZTI-Tecnalia for evaluating the ecological state of the quality of the sea and the estuaries. This is AMBI (the Azti Marine Biotic Index), software that contains data on more than 6,000 species throughout the planet, and which has had great repercussion and use worldwide.
###
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 27-Sep-2012
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